Naringenin Reduces Hepatic Inflammation and Apoptosis Induced by Vancomycin in Rats

Objective: This investigation aimed to detect the possible protective impacts of naringenin (NAR) on vancomycin (VCM)-induced liver toxicity through measuring caspase-3, -8 and -9 activities as markers apoptosis levels tumor necrosis factor-alpha, cyclooxygenase-2 vascular endothelial growth factor inflammation assessing histopathological alterations in rats. Methods: The rats were allocated into seven groups as, control group (saline, intraperitoneally (i.p.)), VCM (400 mg/kg/day, i.p.), Carboxymethyl cellulose (0.5% CMC, orally), NAR100 (100 VCM+NAR25 (25 VCM+NAR50 (50 VCM+NAR100 orally). caspase enzyme measured using colorimetric methods ELISA, respectively. Histopathological examinations performed. Results: significantly higher opposed other groups. ameliorated compared groups, but attenuated and, especially, group. Conclusion: NAR has potential impact injury caused by VCM, at distinct doses may occur via different molecular mechanisms.